Article
Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
Gishizky M L, Johnson-White J, Witte O N
Abstract excerpt
Lethally irradiated mice reconstituted with bone marrow expressing P210 BCR-ABL can develop myeloproliferative syndromes that resemble the initial phase of human chronic myelogenous leukemia (CML). Mice that develop the CML-like syndrome can be segregated into two groups based on the latency with...
Topics
- Animals
- Bone Marrow
- DNA
- Fusion Proteins, bcr-abl
- Genes, abl
- Hematologic Diseases
- Hematopoietic Stem Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Mice
- Mice, Inbred BALB C
- Neoplasm Transplantation
- Oncogenes
- Phenotype