Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid.

Journal of medical genetics - 1 Sept 1997

Smith C A, Wadelius M, Gough A C, Harrison D J, Wolf C R, Rane A

Abstract excerpt

Human arylamine N-acetyltransferase (NAT) activity is determined by two distinct genes, NAT1 and NAT2, and the classical acetylation polymorphism in NAT2 has been associated with a variety of disorders, including lupus erythematosus and arylamine induced cancers. Over 50% of the white population exhibit a slow acetylator phenotype. The genetic basis of the defect has been identified and several DNA based assays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to NAT2 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Isoniazid

Share to Phenotype

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Scotland

Share to Sweden

Source

Open in PubMed Open full text

Identifiers

PMID: 9321764
DOI: 10.1136/jmg.34.9.758
PMCID: PMC1051062

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid.PMID 9321764Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.Semantic proximity Read ↗

Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations.Semantic proximity Read ↗

Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.Semantic proximity Read ↗

Full-gene-sequencing analysis of N-acetyltransferase-2 in an adult Indian population.Semantic proximity Read ↗

Arylamine N-acetyltransferase 2 slow acetylator polymorphisms in unrelated Iranian individuals.Semantic proximity Read ↗

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.Semantic proximity Read ↗

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.Semantic proximity Read ↗

N-acetyltransferase 2 genotyping: an accurate and feasible approach for simultaneous detection of the most common NAT2 alleles.Semantic proximity Read ↗

Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.Semantic proximity Read ↗

Human acetyltransferase polymorphisms.Semantic proximity Read ↗

Polymorphisms of N-acetyltransferase genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.