Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic detection of clonotypic B cells in multiple myeloma by specific immunoglobulin ligands reveals their rarity in multiple myeloma.

PloS one - 1 Jan 2012

Trepel Martin, Martens Victoria, Doll Christian, Rahlff Janina, Gösch Barbara, Loges Sonja, Binder Mascha

Abstract excerpt

In multiple myeloma, circulating "clonotypic" B cells, that express the immunoglobulin rearrangement of the malignant plasma cell clone, can be indirectly detected by PCR. Their role as potential "feeder" cells for the malignant plasma cell pool remains controversial. Here we established for the first time an approach that allows direct tracking of such clonotypic cells by labeling with patient-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Epitopes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Immunoglobulins

Share to Multiple Myeloma

Share to Peptide Library

Share to Remission Induction

Share to Stem Cell Transplantation

Source

Open in PubMed Open full text

Identifiers

PMID: 22384124
DOI: 10.1371/journal.pone.0031998
PMCID: PMC3285203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic detection of clonotypic B cells in multiple myeloma by specific immunoglobulin ligands reveals their rarity in multiple myeloma.PMID 22384124Read ↗

Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma.Semantic proximity Read ↗

Circulating clonotypic B cells in multiple myeloma and monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

A High Frequency of Circulating B Cells Share Clonotypic Ig Heavy-Chain VDJ Rearrangements With Autologous Bone Marrow Plasma Cells in Multiple Myeloma, as Measured by Single-Cell and In Situ Reverse Transcriptase-Polymerase Chain ReactionSemantic proximity Read ↗

Stability and uniqueness of clonal immunoglobulin CDR3 sequences for MRD tracking in multiple myelomaSemantic proximity Read ↗

Deep Sequencing Reveals Oligoclonality At The Immunoglobulin Locus In Multiple Myeloma PatientsSemantic proximity Read ↗

Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma.Semantic proximity Read ↗

Clonotypic Features of Rearranged Immunoglobulin Genes Yield Personalized Biomarkers for Minimal Residual Disease Monitoring in Multiple MyelomaSemantic proximity Read ↗

Single-Cell RNA Sequencing for the Detection of Clonotypic V(D)J Rearrangements in Multiple MyelomaSemantic proximity Read ↗

Phenotypic identification of subclones in multiple myeloma with different chemoresistant, cytogenetic and clonogenic potential.Semantic proximity Read ↗

The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression.Semantic proximity Read ↗

The myeloma stem cell concept, revisited: from phenomenology to operational terms.Semantic proximity Read ↗

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.