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Article

Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.

British journal of haematology - 1 Aug 1994

Takishita M, Kosaka M, Goto T, Saito S

Abstract excerpt

The cellular origin and extent of clonal involvement in multiple myeloma (MM) are controversial. The third-complementarity-determining region (CDR3) of the immunoglobulin heavy chain gene is the target region of VH replacements and somatic mutations. We analysed the CDR3 sequences of myeloma cells from eight newly diagnosed and three relapsed patients in order to elucidate the target cell of malignant...

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Identifiers

PMID: 7986715
DOI: 10.1111/j.1365-2141.1994.tb06732.x

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