Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.

doi:10.1111/j.1365-2141.1994.tb06732.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.

British journal of haematology - 1 Aug 1994

Takishita M, Kosaka M, Goto T, Saito S

Abstract excerpt

The cellular origin and extent of clonal involvement in multiple myeloma (MM) are controversial. The third-complementarity-determining region (CDR3) of the immunoglobulin heavy chain gene is the target region of VH replacements and somatic mutations. We analysed the CDR3 sequences of myeloma cells from eight newly diagnosed and three relapsed patients in order to elucidate the target cell of malignant...

Topics

Aged
Amino Acid Sequence
Base Sequence
Cell Separation
Cell Transformation, Neoplastic
DNA Probes
Female
Flow Cytometry
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Lymphocyte Subsets

Male

Middle Aged

Molecular Sequence Data

Multiple Myeloma

Mutation

Source

Open in PubMed

Identifiers

PMID: 7986715
DOI: 10.1111/j.1365-2141.1994.tb06732.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7986715-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.PMID 7986715Read ↗

Multiple myeloma: new evidence and insights from the immunoglobulin heavy chain gene and phenotypes.Semantic proximity Read ↗

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.Semantic proximity Read ↗

Genetics and cytogenetics of multiple myeloma: a workshop report.Semantic proximity Read ↗

Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.Semantic proximity Read ↗

Circulating clonal lymphocytes in myeloma constitute a minor subpopulation of B cells [see comments]Semantic proximity Read ↗

Circulating clonotypic B cells in multiple myeloma and monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

Genetic Abnormalities and Patterns of Antigenic Expression in Multiple MyelomaSemantic proximity Read ↗

Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients.Semantic proximity Read ↗

Mutational Profile and Prognostic Relevance of Circulating Tumor Cells in Multiple MyelomaSemantic proximity Read ↗

Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation.Semantic proximity Read ↗

The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.