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Article

B cell maturation in relation to multiple myeloma.

Pathologie-biologie - 1 Feb 1999

Stevenson F K, Sahota S S

Abstract excerpt

Maturation of a normal B-cell precursor to a mature plasma cell involves rearrangement and somatic mutation of the immunoglobulin variable (V) region genes. These events occur at distinct stages of development, and when a B cell undergoes neoplastic transformation, the genetic imprint reflects the clonal history of the cell of origin. Sequence analysis of V-genes can reveal bias as compared with the available...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10192875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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