Article
Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.
British journal of haematology - 1 May 1994
Bakkus M H, Van Riet I, Van Camp B, Thielemans K
Abstract excerpt
There is still much controversy about the precursor cell type in multiple myeloma (MM). Some authors claim that it is a pre-B cell, others state that it is a memory B cell or plasmablast. We have recently shown that the VDJ region of the MM immunoglobulin heavy chain gene is somatically hypermutated and antigen selected, without intraclonal variation or evolution in time. By using a patient-specific PCR approach...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.