Article
Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.
British journal of haematology - 1 May 1994
Bakkus M H, Van Riet I, Van Camp B, Thielemans K
Abstract excerpt
There is still much controversy about the precursor cell type in multiple myeloma (MM). Some authors claim that it is a pre-B cell, others state that it is a memory B cell or plasmablast. We have recently shown that the VDJ region of the MM immunoglobulin heavy chain gene is somatically hypermuta...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Humans
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Multiple Myeloma
- Mutation
- Neoplastic Stem Cells
- Polymerase Chain Reaction