Article
Adenomatous polyposis coli gene involvement in ileal enterochromaffin cell neuroendocrine neoplasms.
Human pathology - 1 Dec 2013
Bottarelli Lorena, Azzoni Cinzia, Pizzi Silvia, D'Adda Tiziana, Silini Enrico Maria, Bordi Cesare, Rindi Guido
Abstract excerpt
The adenomatous polyposis coli gene is a key tumor suppressor gene. Alterations in this gene have been found in most sporadic colon cancers; associated with familial adenomatous polyposis; and found in neoplasms of other organs, such as the liver, stomach, lung, breast, and cerebellar medulloblastoma. In the heterogeneous group of neuroendocrine neoplasms of the gastrointestinal tract, the involvement of...
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