Frequent mutations of p53 gene in oesophageal squamous cell carcinomas with and without human papillomavirus (HPV) involvement suggest the dominant role of environmental carcinogens in oesophageal carcinogenesis.

doi:10.1038/bjc.1994.305

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Article

Frequent mutations of p53 gene in oesophageal squamous cell carcinomas with and without human papillomavirus (HPV) involvement suggest the dominant role of environmental carcinogens in oesophageal carcinogenesis.

British journal of cancer - 1 Aug 1994

Chang F, Syrjänen S, Tervahauta A, Kurvinen K, Wang L, Syrjänen K

Abstract excerpt

Epidemiological evidence suggests that alcohol intake, use of tobacco, ingestion of mycotoxins and nitrosamines and nutritional deficiencies are high-risk factors for the development of oesophageal cancer. Similarly, viral infections have been postulated to play a role in some tumours. However, t...

Topics

Adult
Aged
Base Sequence
Carcinogens, Environmental
Carcinoma, Squamous Cell
Chromosome Aberrations
DNA, Single-Stranded
DNA, Viral
Esophageal Neoplasms
Female
Genes, p53
Humans
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Papillomaviridae

Source

Open in PubMed Open full text

Identifiers

PMID: 8054284
DOI: 10.1038/bjc.1994.305
PMCID: PMC2033483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8054284-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.