Article
Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome.
Arthritis and rheumatism - 1 Aug 1994
Gough A, Faint J, Salmon M, Hassell A, Wordsworth P, Pilling D, Birley A, Emery P
Abstract excerpt
OBJECTIVE: To test the hypothesis that genetic characterization of patients at the time they present with inflammatory arthritis can predict subsequent destructive disease. METHODS: We evaluated 177 patients with early arthritis. Patients were serologically tested for rheumatoid factor (RF) and were DNA oligotyped for the presence of conserved base sequences in the third hypervariable region (HVR3) of the DRB1...
Topics
- Alleles
- Arthritis, Rheumatoid
- Follow-Up Studies
- Gene Frequency
- Genes, MHC Class II
- Genotype
- HLA-D Antigens
- HLA-DR Antigens
- Heterozygote
- Histocompatibility Testing
- Homozygote