Article
Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.
The Journal of clinical investigation - 1 May 1995
Weyand C M, McCarthy T G, Goronzy J J
Abstract excerpt
RA is a heterogeneous group of disorders characterized by variations in clinical manifestations, disease course, and probably response to therapeutic interventions. We have addressed the question whether genetically and potentially etiologically more homogeneous subgroups of RA patients can be defined based upon the expression of the RA-linked sequence motif in the third hypervariable region of the HLA-DRB1 gene....
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Base Sequence
- Case-Control Studies
- DNA Primers
- Disease Progression
- Genetic Variation
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains