Article
Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile.
The Journal of rheumatology - 1 Dec 2006
Janssens A Cecile J W, Steyerberg Ewout W, Jiang Yebin, Habbema J Dik F, Van Duijn Cornelia M, Criswell Lindsey A
Abstract excerpt
OBJECTIVE: To investigate the influence of individual patient risk profiles on the value of the HLA-DRB1 shared epitope (SE) as a predictor of severe erosive damage in rheumatoid arthritis (RA). METHODS: Patient characteristics, clinical signs and symptoms, rheumatoid factor (RF) status, and HLA-DRB1 genotypes were available for 154 Caucasian women with RA. Risk profiles were defined by non-genetic factors that...
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