Article
Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: Association with severity and progression of rheumatoid arthritis in a prospective study.
Arthritis and rheumatism - 1 Jul 2002
Constantin Arnaud, Lauwers-Cancès Valérie, Navaux Frédérique, Abbal Michel, van Meerwijk Joost, Mazières Bernard, Cambon-Thomsen Anne, Cantagrel Alain
Abstract excerpt
OBJECTIVE: To test the hypothesis of an association between a polymorphism in the matrix metalloproteinase 3 (MMP-3) gene promoter and the susceptibility, severity, and progression of rheumatoid arthritis (RA), and to further document the association between HLA-DRB1 alleles encoding the shared epitope (SE) and the severity and progression of RA. METHODS: Patients with early RA (n = 103) were included in this...
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