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Article

Monocyte culture and adherence modifies LPS-induced IL-6 production and inhibition by hydrocortisone.

Clinical immunology and immunopathology - 1 Aug 1994

Breuninger L, Goonewardene I M, Dempsey W L, Murasko D M

Abstract excerpt

The effect of hydrocortisone (HC) on IL-6 production by monocytes (Mo) that were cultured under either adherent or limited-adherent culture conditions was determined. Although freshly isolated Mo produced more IL-6 in response to LPS than Mo cultured 24 hr, culture had little effect on inhibition of IL-6 by HC. In contrast, the conditions of Mo culture had a significant impact on the kinetics of IL-6 production...

Topics

Animals
Cell Adhesion
Cell Communication
Cells, Cultured
Drug Interactions
Humans
Hydrocortisone
Interleukin-6
Kinetics
Leukocytes, Mononuclear
Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Phenotype

Time Factors

Source

Identifiers

PMID: 8050200
DOI: 10.1006/clin.1994.1140

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8050200-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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