Article
Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2001
Yoshida M, Sawada T, Ishii H, Gerszten R E, Rosenzweig A, Gimbrone M A, Yasukochi Y, Numano F
Abstract excerpt
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have been reported to exert actions independent of their lipid-lowering effects. To critically assess the effects of statins on monocyte-endothelial cell interactions, we used an in vitro model that mimicked physiological flow conditions. Monocytic U937 cells were incubated in the presence of cerivastatin for 48 hours. Adhesive interactions...
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