Article
Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1. Regulation by Rho and phosphatidylinositol 3-kinase.
The Journal of biological chemistry - 8 Jan 1999
Hmama Z, Knutson K L, Herrera-Velit P, Nandan D, Reiner N E
Abstract excerpt
Mechanisms regulating lipopolysaccharide (LPS)-induced adherence to intercellular adhesion molecule (ICAM)-1 were examined using THP-1 cells transfected with CD14-cDNA (THP-1wt). THP-1wt adherence to ICAM-1 was LPS dose-related, time-dependent, and inhibited by antibodies to either CD14 or leukoc...
Topics
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Line
- Enzyme Activation
- GTP-Binding Proteins
- Guanine Nucleotide Exchange Factors
- Intercellular Adhesion Molecule-1
- Lipopolysaccharide Receptors
- Lipopolysaccharides
- Lymphocyte Function-Associated Antigen-1
- Monocytes
- Phenotype
- Phosphatidylinositol 3-Kinases