Article
Induction of an anti-inflammatory human monocyte subtype is a unique property of glucocorticoids, but can be modified by IL-6 and IL-10.
Immunobiology - 1 Mar 2012
Tsianakas Athanasios, Varga Georg, Barczyk Katarzyna, Bode Guenther, Nippe Nadine, Kran Nelli, Roth Johannes, Luger T A, Ehrchen Jan, Sunderkoetter Cord
Abstract excerpt
Glucocorticoids (GC) are the most widely used immunosuppressive agents in clinical medicine. Recently we showed that GC enhance survival of human monocytes and induce a specific anti-inflammatory monocyte subtype which actively induces resolution of inflammation. We now investigated if cytokines IL-4, IL-6 and IL-10, which, like GC, have mostly anti-inflammatory effects on macrophages, would have GC-like effects...
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