Article
Antiestrogens activate an estrogen receptor mutant exhibiting enhanced binding to the estrogen response element.
Biochemical and biophysical research communications - 29 Jul 1994
Xing H, Haase S, Shapiro D J
Abstract excerpt
The appearance of constitutively active and antiestrogen resistant estrogen receptor variants has been proposed as one of several factors leading to the development of antiestrogen resistant breast cancers. We recently described the ER2, estrogen receptor mutant, which exhibits enhanced binding to the estrogen response element on DNA, and partial constitutive estrogen-independent) ability to activate...
Topics
- Animals
- Cell Line
- DNA
- Drug Resistance
- Estradiol
- Estrogen Antagonists
- HeLa Cells
- Humans
- Liver
- Mutation
- Polyunsaturated Alkamides
- Promoter Regions, Genetic