Article
Transfection of human estrogen receptor (ER) cDNA into ER-negative mammalian cell lines.
The Journal of steroid biochemistry and molecular biology - 1 Dec 1994
Levenson A S, Jordan V C
Abstract excerpt
Estrogen responsiveness of breast tumors can be correlated with the presence or absence of the estrogen receptor (ER). Breast cancer cells that contain ER are, in general, responsive to stimulation by estrogen both in vivo and in vitro; therefore hormonal control is possible. Breast tumors that lose the ER, and become hormone-independent are refractory to the direct effect of estrogens and antiestrogens. It is...
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