Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens.

Article

Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens.

Cancer research - 1 Mar 1998

Tremblay G B, Tremblay A, Labrie F, Giguère V

Abstract excerpt

It has recently been suggested that mutation of a conserved tyrosine to asparagine within the ligand-binding domain of the estrogen receptor (ER) alpha confers hormone-independent activation and insensitivity to antiestrogens (Q. X. Zhang et al., Cancer Res., 57: 1244-1249, 1997). In view of the...

Topics

Animals
COS Cells
Estrogen Antagonists
Estrogen Receptor alpha
Estrogen Receptor beta
Humans
Ligands
Mutation
Receptors, Estrogen
Signal Transduction
Tyrosine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.