Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.

doi:10.1210/mend.8.10.7531820

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Article

Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 1994

Ince B A, Montano M M, Katzenellenbogen B S

Abstract excerpt

We show that some transcriptionally inactive human estrogen receptor (ER) mutants can be activated by 17 beta-estradiol (E2), and sometimes by antiestrogens, in the presence of elevated levels of intracellular cAMP. ER-deficient Chinese hamster ovary or 3T3 mouse fibroblast cells were transfected with mutant ERs (the point mutant L540Q, the frameshift mutant S554fs, or the carboxy-terminal truncated receptor...

Topics

1-Methyl-3-isobutylxanthine
3T3 Cells
Animals
Base Sequence
CHO Cells
Cholera Toxin
Cricetinae
Cyclic AMP
Estradiol
Estrogen Antagonists
Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Molecular Sequence Data

Mutagenesis

Mutation

Receptors, Estrogen

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7531820
DOI: 10.1210/mend.8.10.7531820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7531820-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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