Article
Preferential utilization of the immature JH segment and absence of somatic mutation in the CDR3 junction of the Ig H chain gene in three X-linked severe combined immunodeficiency patients.
International immunology - 1 Nov 1994
Minegishi Y, Okawa H, Sugamura K, Yata J
Abstract excerpt
Human severe combined immunodeficiency (SCID) includes an X-linked SCID (XSCID) characterized by a complete absence of mature T cells, hypogammaglobulinemia and a normal or elevated number of B cells. XSCID results from mutation in the IL-2 receptor (IL-2R) gamma chain gene, which is thought to b...
Topics
- B-Lymphocytes
- Base Sequence
- DNA
- Genetic Linkage
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Infant
- Male
- Molecular Sequence Data