The mouse severe combined immune deficiency (scid) mutation is closely linked to the B-cell-specific developmental genes VpreB and lambda 5.

doi:10.1006/geno.1993.1256

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Article

The mouse severe combined immune deficiency (scid) mutation is closely linked to the B-cell-specific developmental genes VpreB and lambda 5.

Genomics - 1 Jun 1993

Miller R D, Ozaki J H, Riblet R

Abstract excerpt

The mouse severe combined immune deficiency (scid) phenotype is due to a recessive, autosomal mutation which results in failed development of lymphocytes. An important step during normal lymphocyte development is the germline rearrangement of DNA segments to assemble functional immunoglobulin or...

Topics

Animals
B-Lymphocytes
Blotting, Southern
Cell Differentiation
Crosses, Genetic
Female
Genetic Linkage
Mice
Mice, SCID
Mutation
Polymorphism, Restriction Fragment Length

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