Molecular genotyping of the mouse scid allele.

Abstract excerpt

Severe combined immunodeficiency (SCID) mice, which lack mature B- and T-cells, provide an important system for studies on immunity and disease. However, since the scid mutation is a single T-to-A transversion, genotypic analysis can be problematic. We have developed a rapid and simple sequence-based analysis that provides identification of both the scid and the wild-type (+) allele. This allows unequivocal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to DNA-Activated Protein Kinase
• Share to DNA-Binding Proteins