Article
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.
Immunity - 1 Jan 1996
Burshtyn D N, Scharenberg A M, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet J P, Long E O
Abstract excerpt
Cytolysis of target cells by natural killer (NK) cells and by some cytotoxic T cells occurs unless prevented by inhibitory receptors that recognize MHC class I on target cells. Human NK cells express a p58 inhibitory receptor specific for HLA-C. We report association of the tyrosine phosphatase H...
Topics
- Amino Acid Sequence
- Cell Line
- Cytotoxicity, Immunologic
- HLA-C Antigens
- Humans
- Killer Cells, Natural
- Molecular Sequence Data
- Mutation
- Protein Tyrosine Phosphatases
- Receptors, Cytoplasmic and Nuclear
- Receptors, Immunologic
- Lamin B Receptor