Clonal evolution of a follicular lymphoma: evidence for antigen selection.

doi:10.1073/pnas.89.15.6770

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Article

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992

Bahler D W, Levy R

Abstract excerpt

The potential role antigens play in growth stimulation or in clonal selection of follicular lymphomas is unknown. To study this issue, we sequenced the immunoglobulin heavy chain variable region genes expressed by a follicular lymphoma from multiple biopsy specimens and also cloned and sequenced the corresponding germ-line variable gene from this patient. Comparison to the germ-line gene revealed numerous...

Topics

Antigens, Neoplasm
B-Lymphocytes
Base Sequence
Cloning, Molecular
DNA, Neoplasm
Genes, Immunoglobulin
Genetic Variation
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Follicular

Molecular Sequence Data

Oligodeoxyribonucleotides

Phenotype

Polymerase Chain Reaction

Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 1495966
DOI: 10.1073/pnas.89.15.6770
PMCID: PMC49585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1495966-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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