Article
The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.
Science (New York, N.Y.) - 23 Jun 2006
Okada Kumiko, Inoue Akane, Okada Momoko, Murata Yoji, Kakuta Shigeru, Jigami Takafumi, Kubo Sachiko, Shiraishi Hirokazu, Eguchi Katsumi, Motomura Masakatsu, Akiyama Tetsu, Iwakura Yoichiro, Higuchi Osamu, Yamanashi Yuji
Abstract excerpt
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of...
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