Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.

The Journal of cell biology - 6 Aug 2012

Schmidt Nadine, Basu Sreya, Sladecek Stefan, Gatti Sabrina, van Haren Jeffrey, Treves Susan, Pielage Jan, Galjart Niels, Brenner Hans Rudolf

Abstract excerpt

Agrin is the major factor mediating the neuronal regulation of postsynaptic structures at the vertebrate neuromuscular junction, but the details of how it orchestrates this unique three-dimensional structure remain unknown. Here, we show that agrin induces the formation of the dense network of microtubules in the subsynaptic cytoplasm and that this, in turn, regulates acetylcholine receptor insertion into the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycogen Synthase Kinase 3
Share to Glycogen Synthase Kinase 3 beta

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Microtubules

Share to Neuromuscular Junction

Share to Phosphatidylinositol 3-Kinases

Share to Receptors, Cholinergic

Share to Synaptic Membranes

Source

Open in PubMed Open full text

Identifiers

PMID: 22851317
DOI: 10.1083/jcb.201111130
PMCID: PMC3413356

Genes

CLASP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.PMID 22851317Read ↗

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndromeSemantic proximity Read ↗

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.Semantic proximity Read ↗

The many roles of dystroglycan in nervous system development and functionSemantic proximity Read ↗

The function of cortactin in the clustering of acetylcholine receptors at the vertebrate neuromuscular junction.Semantic proximity Read ↗

A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion.Semantic proximity Read ↗

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.Semantic proximity Read ↗

F-BAR proteins of the syndapin family shape the plasma membrane and are crucial for neuromorphogenesis.Semantic proximity Read ↗

The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functionsSemantic proximity Read ↗

Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.Semantic proximity Read ↗

The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.Semantic proximity Read ↗

Mask, the <i>Drosophila</i> Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamicsSemantic proximity Read ↗

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hubSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.