Article
Impaired IgE response in SWAP-70-deficient mice.
European journal of immunology - 1 Aug 2001
Borggrefe T, Keshavarzi S, Gross B, Wabl M, Jessberger R
Abstract excerpt
Protein SWAP-70 was initially isolated from nuclei of activated B cells and was implicated in the immunoglobulin class switch process. After B cell activation the protein translocates from the cytoplasm to the nucleus, and may serve to signal nuclear processes. We have generated mice deficient in SWAP-70 and found three main differences when compared to wild-type mice: (i) their B lymphocytes are two- to...
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