Article
Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.
The EMBO journal - 1 Jul 1994
Barettino D, Vivanco Ruiz M M, Stunnenberg H G
Abstract excerpt
Transcriptional activation by nuclear receptors is achieved through autonomous activation functions (AFs), a constitutive N-terminal AF-1 and a C-terminal, ligand-dependent AF-2 that comprises a motif conserved between nuclear receptors. We have performed an extensive mutational analysis of the p...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cell Line
- Chickens
- Conserved Sequence
- Ligands
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Receptors, Thyroid Hormone
- Recombinant Fusion Proteins