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Article

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated Receptor

12 Sept 2008

Abstract excerpt

The chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and II) make up the most conserved subfamily of nuclear receptors that play key roles in angiogenesis, neuronal development, organogenesis, cell fate determination, and metabolic homeostasis. Although the biological functions of COUP-TFs have been studied extensively, little is known of their structural features or aspects of ligand...

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PMID: 18798693
DOI: 10.1371/journal.pbio.0060227

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Research trail→

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Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorPMID 18798693Read ↗

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actionsSemantic proximity Read ↗

COUP-TF orphan nuclear receptors in development and differentiationSemantic proximity Read ↗

COUP-TFII Regulates Human Endometrial Stromal Genes Involved in InflammationSemantic proximity Read ↗

Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Dimers Bind to Different GGTCA Response Elements, Allowing COUP-TF To Repress Hormonal Induction of the Vitamin D<sub>3</sub>, Thyroid Hormone, and Retinoic Acid ReceptorsSemantic proximity Read ↗

The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.Semantic proximity Read ↗

Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiencySemantic proximity Read ↗

Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.Semantic proximity Read ↗

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatmentSemantic proximity Read ↗

Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cellsSemantic proximity Read ↗

COUP-TFI and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity.Semantic proximity Read ↗

Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.Semantic proximity Read ↗

The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.Semantic proximity Read ↗

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