Article
Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.
The EMBO journal - 1 Mar 1992
Danielian P S, White R, Lees J A, Parker M G
Abstract excerpt
The oestrogen receptor stimulates transcription by means of at least two distinct transcriptional activation domains, TAF-1 in the N-terminal domain and TAF-2 in the hormone binding domain. Here we show that TAF-2 activity requires a region in the C-terminus of the hormone binding domain between residues 538 and 552 in the mouse oestrogen receptor which is conserved among many nuclear hormone receptors. Point...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Line
- DNA
- Genetic Vectors
- Ligands
- Mice
- Molecular Sequence Data
- Mutation
- Protein Biosynthesis
- RNA