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Article

Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.

Genes & development - 1 Jun 1997

Mengus G, May M, Carré L, Chambon P, Davidson I

Abstract excerpt

We report for the first time the cloning of a complete cDNA encoding the human TFIID subunit hTAF(II)135 (hTAF(II)130). Full-length hTAF(II)135 comprises 1083 amino acids and contains two conserved domains present also in dTAF(II)110 and hTAF(II)105. We show that expression of hTAF(II)135 in mammalian cells strongly and selectively potentiates transcriptional stimulation by the activation function-2 (AF-2) of the...

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Source

Identifiers

PMID: 9192867
DOI: 10.1101/gad.11.11.1381

Genes

TBP
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.PMID 9192867Read ↗

Human TAFII105 Is a Cell Type–Specific TFIID Subunit Related to hTAFII130Semantic proximity Read ↗

Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription.Semantic proximity Read ↗

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.Semantic proximity Read ↗

Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2).Semantic proximity Read ↗

Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators.Semantic proximity Read ↗

Two Novel <i>Drosophila</i> TAF<sub>II</sub>s Have Homology with Human TAF<sub>II</sub>30 and Are Differentially Regulated during DevelopmentSemantic proximity Read ↗

Architecture of TAF11/TAF13/TBP complex suggests novel regulatory state in General Transcription Factor TFIID functionSemantic proximity Read ↗

The N-terminal domain of human TAFII68 displays transactivation and oncogenic propertiesSemantic proximity Read ↗

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorSemantic proximity Read ↗

TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB.Semantic proximity Read ↗

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.Semantic proximity Read ↗

Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun.Semantic proximity Read ↗

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