Article
p53 gene mutations in human gastric cancer: wild-type p53 but not mutant p53 suppresses growth of human gastric cancer cells.
Cancer research - 15 Aug 1992
Matozaki T, Sakamoto C, Suzuki T, Matsuda K, Uchida T, Nakano O, Wada K, Nishisaki H, Konda Y, Nagao M
Abstract excerpt
To further investigate the role of p53 gene inactivation in gastric tumorigenesis, the mutational status of the p53 gene in primary human gastric cancer samples was examined. Reverse transcriptase polymerase chain reaction and subsequent direct sequencing of the p53 gene from gastric cancer samples revealed frequent point mutations of the p53 gene: some of these coincided with those previously identified in...
Topics
- Antigens, Viral, Tumor
- Base Sequence
- Blotting, Southern
- Cell Division
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Codon
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data