Article
Comparison of p53 gene mutations in paired primary and metastatic gastric tumor tissues.
Journal of Korean medical science - 1 Jun 1993
Kim J H, Choi J J, Noh S H, Roh J K, Min J S, Youn J K, Yoo N C, Lim H Y, Carbone D P, Gazdar A F
Abstract excerpt
Our previous study revealed that mutations of the p53 gene were detected by cDNA sequencing in one of four (25%) primary gastric tumors and in five of six (83%) gastric cancer cell lines. It was of interest that all five cell lines established from metastatic lesions had p53 gene mutations, while...
Topics
- Base Sequence
- Chromosome Deletion
- DNA, Complementary
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Metastasis
- Polymorphism, Restriction Fragment Length
- RNA, Messenger
- Stomach Neoplasms