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Article

G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation.

The Journal of biological chemistry - 24 Dec 2004

Lee Yi-Nan, Malbon Craig C, Wang Hsien-yu

Abstract excerpt

The heterotrimeric G-protein G(13) mediates the formation of primitive endoderm from mouse P19 embryonal carcinoma cells in response to retinoic acid, signaling to the level of activation of c-Jun N-terminal kinase. The signal linkage map from MEKK1/MEKK4 to MEK1/MKK4 to JNK is obligate in this G alpha(13)-mediated pathway, whereas that between G alpha(13) and MEKKs is not known. The overall pathway to primitive...

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PMID: 15492006
DOI: 10.1074/jbc.M407581200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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