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Article

A region close to Tp53 shows LOH in familial breast cancer.

International journal of molecular medicine - 1 Apr 2002

Luo Liping, Chen Jindong, Du Quan, Dumanski Jan, Blennow Elisabeth, Kockum Ingrid, Luthman Holger, Lindblom Annika

Abstract excerpt

The proportions of mutation of BRCA1 and BRCA2 detected in familial breast cancer vary in different regions. Most breast cancer families in Sweden cannot be explained by mutations in the known major susceptibility genes. Our previous studies have found a high frequency of LOH in the Tp53 region in familial breast cancer suggesting a putative tumor suppressor gene in this region, and the Tp53 gene was excluded as...

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Source

Identifiers

PMID: 11891537

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A region close to Tp53 shows LOH in familial breast cancer.PMID 11891537Read ↗

Evidence for a gene on 17p13.3, distal to TP53, as a target for allele loss in breast tumors without p53 mutations.Semantic proximity Read ↗

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.Semantic proximity Read ↗

Four separate regions on chromosome 17 show loss of heterozygosity in familial breast carcinomas.Semantic proximity Read ↗

Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context.Semantic proximity Read ↗

Evidence for involvement of BRCA1 in sporadic breast carcinomas.Semantic proximity Read ↗

Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.Semantic proximity Read ↗

[Detection of genetic alterations in sporadic breast tumors].Semantic proximity Read ↗

Patterns of allelic loss on chromosome 17 in sporadic breast carcinomas detected by fluorescent-labeled microsatellite analysis.Semantic proximity Read ↗

Allelic loss at BRCA1, BRCA2, and adjacent loci in relation to TP53 abnormality in breast cancer.Semantic proximity Read ↗

Sporadic breast carcinomas with somatic BRCA1 gene deletions share genotype/phenotype features with familial breast carcinomas.Semantic proximity Read ↗

Evidence for a second tumor suppressor gene on 17p linked to high S-phase index in primary human breast carcinomas.Semantic proximity Read ↗

CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.Semantic proximity Read ↗

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