Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.

Article

Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.

Cancer research - 15 Jul 1994

Hayashi N, Arakawa H, Nagase H, Yanagisawa A, Kato Y, Ohta H, Takano S, Ogawa M, Nakamura Y

Abstract excerpt

The mutant allele-specific amplification (MASA) method is capable of detecting one tumor cell containing genetic changes in a sample containing thousands of normal cells. To investigate whether MASA can be applied to sensitive detection of lymph node metastasis, we screened 22 colorectal cancers...

Topics

Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
Female
Genes, p53
Genes, ras
Humans
Lymphatic Metastasis
Male
Middle Aged
Mutation
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.