Article
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Cancer research - 15 Nov 2000
Hashimoto T, Kobayashi Y, Ishikawa Y, Tsuchiya S, Okumura S, Nakagawa K, Tokuchi Y, Hayashi M, Nishida K, Hayashi S, Hayashi J, Tsuchiya E
Abstract excerpt
The predictive value of lymph node micrometastasis, detected by immunohistochemical or genetic methods, is well appreciated in terms of prognosis. However, a major problem is high false-positive rates, because most methods focus on cytokeratin, which is a component not only of carcinoma but also normal epithelial and nonepithelial cells. Mutant allele-specific amplification (MASA) can detect DNAs derived from...
Topics
- Adenocarcinoma
- Adult
- Aged
- Alleles
- Carcinoma, Squamous Cell
- Female
- Humans
- Immunohistochemistry
- Keratins
- Lung Neoplasms
- Lymph Nodes
- Lymphatic Metastasis
- Male
- Middle Aged