Article
Genetic diagnosis of lymph-node metastasis in colorectal cancer.
Lancet (London, England) - 20 May 1995
Hayashi N, Ito I, Yanagisawa A, Kato Y, Nakamori S, Imaoka S, Watanabe H, Ogawa M, Nakamura Y
Abstract excerpt
If a regional lymph node taken during surgery for colorectal cancer is found to be free of tumour on histological examination this is taken to be a good sign. However, conventional staining may not be sensitive enough. Mutant-allele-specific amplification (MASA) is a technique that can detect, at the level of an individual cell, micrometastases to lymph nodes that are histologically diagnosed as negative. To...
Topics
- Colorectal Neoplasms
- DNA, Neoplasm
- Genes, p53
- Genes, ras
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Mutation
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Polymerase Chain Reaction