Article
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
International journal of cancer - 1 Sept 2004
Taback Bret, Bilchik Anton J, Saha Sukamal, Nakayama Takahiro, Wiese David A, Turner Roderick R, Kuo Christine T, Hoon Dave S B
Abstract excerpt
Inaccurate staging of colorectal cancer (CRC) has been attributed to the failure to detect lymph node metastases by conventional pathology. We have previously reported the use of lymphatic mapping to accurately identify those lymph nodes most likely to harbor micrometastatic disease and permit focused pathologic examination. Mutation of K-ras allele at codons 12 or 13 occurs frequently in early stages of CRC...
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