Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limitations in molecular detection of lymph node micrometastasis from colorectal cancer.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 2007

Klebig Felix, Fischer Carsten, Petri Susan, Gerull Helwe, Wagener Christoph, Tschentscher Peter

Abstract excerpt

Colorectal cancer patients with lymph node metastasis have a shorter survival and may require adjuvant therapy after surgery of the primary tumor. It is supposed that a more reliable diagnosis can be achieved using tumor-specific DNA mutations for the detection of metastasizing cells. To design a practical approach for a molecular diagnosis of micrometastasis, we applied direct DNA sequencing to screen 48 early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, p53
Share to Genes, ras

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Adenocarcinoma

Share to Colorectal Neoplasms

Share to DNA, Neoplasm

Share to Genes, APC

Share to Lymph Nodes

Share to Lymphatic Metastasis

Source

Identifiers

PMID: 17525678
DOI: 10.1097/PDM.0b013e31803278ee

Genes

KRAS
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limitations in molecular detection of lymph node micrometastasis from colorectal cancer.PMID 17525678Read ↗

Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.Semantic proximity Read ↗

Genetic diagnosis of lymph-node metastasis in colorectal cancer.Semantic proximity Read ↗

Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.Semantic proximity Read ↗

Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.Semantic proximity Read ↗

Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.Semantic proximity Read ↗

Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.Semantic proximity Read ↗

Genetic detection of lymph node micrometastases: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer.Semantic proximity Read ↗

Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.Semantic proximity Read ↗

Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.Semantic proximity Read ↗

K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.Semantic proximity Read ↗

Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.Semantic proximity Read ↗

Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.