Article
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1999
Sanchez-Cespedes M, Esteller M, Hibi K, Cope F O, Westra W H, Piantadosi S, Herman J G, Jen J, Sidransky D
Abstract excerpt
Disseminated disease, especially to the liver, constitutes the major risk of recurrence for colorectal cancer patients. However, successful resection can still be achieved in 25-35% of colorectal cancer patients with isolated metastases. To evaluate the clinical value of occult micrometastatic disease detection in lymph nodes, we tested genetic (K-ras and p53 gene mutations) and epigenetic (p16 promoter...
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