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Article

Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer.

Cancer research - 15 Feb 2000

Lehman T A, Haffty B G, Carbone C J, Bishop L R, Gumbs A A, Krishnan S, Shields P G, Modali R, Turner B C

Abstract excerpt

Previous studies have determined that the frequency of germ-line p53 mutations in familial breast cancer patients is 1% or less, but these reports have not investigated the importance of polymorphic intron base changes in the p53 gene. Therefore, we investigated the frequency of both exon and intron germ-line p53 base changes in 42 breast cancer patients with a strong family history of breast cancer. The mean age...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10706125

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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