Article
P53 gene mutations in women with breast cancer and a previous history of benign breast disease.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Seth A, Palli D, Mariano J M, Metcalf R, Venanzoni M C, Bianchi S, Kottaridis S D, Papas T S
Abstract excerpt
Mutations of the p53 tumour suppressor gene are the most common genetic lesions in human cancers and have been reported in breast cancer as part of the Li-Fraumeni syndrome. In the present study, we determined frequencies and types of the p53 mutations in breast cancer tissues in women with a his...
Topics
- Base Sequence
- Breast Diseases
- Breast Neoplasms
- Codon
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neoplastic Syndromes, Hereditary
- Polymerase Chain Reaction
- Precancerous Conditions