Article
p53 alteration in morphologically normal/benign breast luminal cells in BRCA carriers with or without history of breast cancer.
Human pathology - 1 Oct 2017
Wang Xi, El-Halaby Amber A, Zhang Hengwei, Yang Qi, Laughlin Todd S, Rothberg Paul G, Skinner Kristin, Hicks David G
Abstract excerpt
Germline mutations in BRCA genes have been shown to predispose patients to breast cancer. Studies have suggested that p53 alteration is a necessary step in tumorigenesis in BRCA carriers. Our previous study showed p53 alteration in morphologically normal/benign breast luminal cells in sporadic breast cancer patients, the so-called breast p53 signature. Here, we studied p53 status in 66 BRCA1/2 carriers' breasts:...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Biomarkers, Tumor
- Cell Transformation, Neoplastic
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Genomic Instability
- Heredity
- Heterozygote
- Humans
- Immunohistochemistry
- Mutation