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p53 alteration in morphologically normal/benign breast luminal cells in BRCA carriers with or without history of breast cancer.

Human pathology - 1 Oct 2017

Wang Xi, El-Halaby Amber A, Zhang Hengwei, Yang Qi, Laughlin Todd S, Rothberg Paul G, Skinner Kristin, Hicks David G

Abstract excerpt

Germline mutations in BRCA genes have been shown to predispose patients to breast cancer. Studies have suggested that p53 alteration is a necessary step in tumorigenesis in BRCA carriers. Our previous study showed p53 alteration in morphologically normal/benign breast luminal cells in sporadic breast cancer patients, the so-called breast p53 signature. Here, we studied p53 status in 66 BRCA1/2 carriers' breasts:...

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Source

Identifiers

PMID: 28438622
DOI: 10.1016/j.humpath.2017.04.007

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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