Article

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species

2020-07-18

Abstract excerpt

Vapendavir is a rhino/enterovirus inhibitor that targets a hydrophobic pocket in the viral capsid. Drug-resistant variants were selected in vitro . Mutations in the drug-binding pocket in VP1 (C199R/Y in hRV14; I194F in PV1; M252L and A156T in EV-D68), typical for this class of compounds, were identified. We also observed mutations that are located outside the pocket (K167E in EV-D68 and G149C in hRV2) and that c...

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Literature Corpus work: 6c55e6bb-92fc-5401-bb75-8ac4756ba7f9
DOI: 10.1101/2020.07.16.207373

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