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Article

Characterization of poliovirus variants selected for resistance to the antiviral compound V-073.

Antimicrobial agents and chemotherapy - 1 Nov 2012

Liu Hong-Mei, Roberts Jason A, Moore Deborah, Anderson Barbara, Pallansch Mark A, Pevear Daniel C, Collett Marc S, Oberste M Steven

Abstract excerpt

V-073, a small-molecule capsid inhibitor originally developed for nonpolio enterovirus indications is considerably more potent against polioviruses. All poliovirus isolates tested to date (n = 45), including wild, vaccine, vaccine-derived, and laboratory strains, are susceptible to the antiviral capsid inhibitor V-073. We grew poliovirus in the presence of V-073 to allow for the identification of variants with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22890765
DOI: 10.1128/AAC.00539-12
PMCID: PMC3486616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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