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Article

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species.

Antiviral research - 1 Nov 2021

Lanko Kristina, Sun Liang, Froeyen Mathy, Leyssen Pieter, Delang Leen, Mirabelli Carmen, Neyts Johan

Abstract excerpt

Vapendavir is a rhino/enterovirus inhibitor that targets a hydrophobic pocket in the viral capsid preventing the virus from entering the cell. We set out to study and compare the molecular mechanisms of resistance to vapendavir among clinically relevant Picornavirus species. To this end in vitro resistance selection of drug-resistant isolates was applied in rhinovirus 2 and 14, enterovirus-D68 and Poliovirus 1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34517053
DOI: 10.1016/j.antiviral.2021.105177
PMCID: PMC8593553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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