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Article

New small-molecule inhibitors effectively blocking picornavirus replication.

Journal of virology - 1 Oct 2014

Ford Siltz Lauren A, Viktorova Ekaterina G, Zhang Ben, Kouiavskaia Diana, Dragunsky Eugenia, Chumakov Konstantin, Isaacs Lyle, Belov George A

Abstract excerpt

UNLABELLED: Few drugs targeting picornaviruses are available, making the discovery of antivirals a high priority. Here, we identified and characterized three compounds from a library of kinase inhibitors that block replication of poliovirus, coxsackievirus B3, and encephalomyocarditis virus. Using an in vitro translation-replication system, we showed that these drugs inhibit different stages of the poliovirus...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25008939
DOI: 10.1128/JVI.01877-14
PMCID: PMC4178779

Genes

GBF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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