Article
New small-molecule inhibitors effectively blocking picornavirus replication.
Journal of virology - 1 Oct 2014
Ford Siltz Lauren A, Viktorova Ekaterina G, Zhang Ben, Kouiavskaia Diana, Dragunsky Eugenia, Chumakov Konstantin, Isaacs Lyle, Belov George A
Abstract excerpt
UNLABELLED: Few drugs targeting picornaviruses are available, making the discovery of antivirals a high priority. Here, we identified and characterized three compounds from a library of kinase inhibitors that block replication of poliovirus, coxsackievirus B3, and encephalomyocarditis virus. Using an in vitro translation-replication system, we showed that these drugs inhibit different stages of the poliovirus...
Topics
- 1-Phosphatidylinositol 4-Kinase
- Animals
- Antiviral Agents
- Cell-Free System
- Disease Models, Animal
- Encephalomyocarditis virus
- Enterovirus B, Human
- Gene Expression Regulation, Viral
- HeLa Cells
- Humans