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Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘Senescent’ Cell Populations Be Defined?

3 Sept 2009

Abstract excerpt

The long-term in vitro growth characteristics of peripheral, nonspecifically expanded T cell clones from young (< 30 years old) and old (> 65 years old) Senieur-protocol compatible healthy blood donors were compared. Additionally, T cell clones derived from the sites of autoimmune events were studied. Until the 6th week in culture all clones showed a progressive increase in cell number. CD25 expression and...

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PMID: 8032234
DOI: 10.1159/000236671

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